Up to this point, the first-line treatment for HE/SREAT has been steroids because most, although not all, HE/SREAT patients respond to steroid treatment.
For severely affected patients who have been hospitalized due to the severity of their condition, treatment is often initiated with a course of high dose IV Methylprednisolone
(1 g/day) for 3–7 days. Symptoms may begin to alleviate within as little as 1-2 days, although improvement is more commonly seen on or after day 3-4.
Patients receiving such treatment often return home on an oral dose of 60 mg/day prednisone, which is slowly tapered down over six to twelve months.
Other treatments include azathioprine, cyclophosphamide, chloroquine, methotrexate, periodic intravenous immunoglobulin (IVIG), and plasma exchange. The optimal treatment is not yet clear,
and in fact some HE/SREAT patients respond well to one treatment protocol but get no relief from another.
The Autoimmune Encephalitis Alliance, which addresses over a dozen types of autoimmune encephalitis, provides an excellent overview of treatment options at its website –
Last edited by Web Team on June 20th, 2016