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UPENN Publishes Updated List of Known Autoantibodies

As many visitors to our website may already know, University of Pennsylvania has their own clinic manned by Doctors Eric Lancaster and Josep Dalmau. This clinic has it’s own proprietary laboratory which using immunohistochemistry to identify serum and/or CSF samples that are shown to have immunoreactivity with the brain. We are told that these are most often the patients that receive an autoimmune encephalitis/encephalopathy diagnosis from Dr. Lancaster and Dr. Dalmau’s team of doctors at UPENN.

This list may be a great resource tool for patients, families, and caregivers who wish to learn more about autoimmune encephalitis/encephalopathy and the diagnostic procedure at UPENN.

We encourage you to read more on the UPENN website [].

Hashimoto’s Encephalopathy Articles Published in 2010

Articles on Hashimoto’s Encephalopathy Published in 2010

New Daily Persistent Headache As A Presenting Symptom Of Hashimoto’s Encephalopathy

Dr. Daniel E Jacome

WebmedCentral NEUROLOGY 2010;1(10):WMC00960

Full Text:

Successful response to intravenous immunoglobulin as rescue therapy in a patient with Hashimoto’s encephalopathy.

R. Cornejo, P Venegas, D Goñi, A Salas, and C Romero

BMJ Case Rep. 2010 Dec 29

Full Text:


Paediatric Hashimoto encephalopathy, refractory epilepsy and immunoglobulin treatment – unusual case report and review of the literature

Berger I, Castiel Y, Dor T.

Acta Paediatr. 2010 Dec,  99(12):1903-5.


A series report of autoimmune hypothyroidism associated with Hashimoto’s encephalopathy: an under diagnosed clinical entity with good prognosis.

HK Nayak, MK Daga, R Kumar, SK Garg, N Kumar, PK Mohanty PK

BMJ Case Rep. 2010 Nov 23;2010. pii: bcr0120102630.


Hashimoto encephalopathy: clinical and MRI improvement following high-dose corticosteroid therapy.

T Chang, MT Riffsy, PS Gunaratne

Neurologist. 2010 Nov;16(6):394-6.


Hashimoto’s encephalopathy presenting with neurocognitive symptoms: a case report

Carlos Canelo-Aybar, David Loja-Oropeza, Jose Cuadra-Urteaga and Franco Romani-Romani

Journal of Medical Case Reports 2010, 4:337  (October 25, 2010)

Full Text:

Autoimmune dementia: clinical course and predictors of immunotherapy response

Eoin P. Flanagan, MBBCh, Andrew McKeon, MBBCh, Vanda A. Leonnon, MD, PhD, Bradley F. Boeve, MD, Max R. Trenerry, PhD, K. Meng Tan, MD, Daniel A. Drubach, MD, Keith A. Josephs, MD, Jeffrey W. Britton, MD, Jayawant N. Mandrekar, PhD, Val Lowe, MD, Joseph E. Parisi, MD, and Sean J. Pittock, MD.

Mayo Clin Proc. 2010 October; Volume 85 , Issue 10 pp. 881–897

Full Text:


Electrophysiological tests in a case of Hashimoto’s encephalopathy

S Shibayama, A Igaki, M Kuroda, M Honnda, S Fujii, Y Wada, K Inuzumi, M Takeda, M Koshiba

Rinsho Byori. 2010 Oct;58(10):986-9.



Hashimoto encephalopathy with fulminant myocarditis.

M Podberezin, MN Meriggioli, A Locante, A Voros, T Valyi-Nagy, A Kajdacsy-Balla

Pathol Res Pract. 2010 Oct 15;206(10):720-2.



Clinical Reasoning: A 9-year-old girl with seizures and encephalopathy

Thy P. Nguyen and Lisa M. El-Hakam

Neurology. 2010 June 1; 74(22): e97–e100

Full Text:

Steroid responsive encephalopathy associated with autoimmune thyroiditis presenting with late onset depression.

FA Babtain

Neurosciences (Riyadh). 2010 Jul;15(3):196-9.



Steroid-responsive myeloneuropathy associated with antithyroid antibodies

J Spinal Cord Med. 2010 June – Volume 33, Issue 3, pp. 278–280.

Recai Turkoglu, MD and Erdem Tuzun, MD

Full Text:


Steroid responsive encephalopathy in cerebral amyloid angiopathy: a case report and review of evidence for immunosuppressive treatment

Raoul P Kloppenborg, Edo Richard, Marieke ES Sprengers, Dirk Troost, Piet Eikelenboom and Paul J Nederkoorn

Journal of Neuroinflammation: 2010  –Volume 7, p. 18

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Encephalopathy associated with autoimmune thyroid disease in patients with Graves’ disease: clinical manifestations, follow-up, and outcomes

Gianluca Tamagno, Yahya Celik, Rafael Simó, Marcel Dihné, Kazumi Kimura, Giorgio Gelosa, Byung I Lee, Caroline Hommet and Giovanni Murialdo

BMC Neurology: 2010 – 10:27

Full Text:


Hashimoto encephalopathy in a preschool girl.

M. Castro-Gago, C. Gómez-Lado, M. Maneiro-Freire, J. Eirís-Puñal, M. Bravo-Mata

Pediatr Neurol. 2010 Feb;42(2):143-6.


Undetected Hashimoto encephalopathy–a diagnostic challenge in child psychiatry and child neurology.

R Voll

Z Kinder Jugendpsychiatr Psychother. 2010 Jan;38(1):21-7. (German)


Clinical manifestations, diagnostic criteria and therapy of Hashimoto’s encephalopathy: report of two cases.

Mijajlovic M, Mirkovic M, Dackovic J, Zidverc-Trajkovic, J, Sternic N.

J. Neurol Sci: 2010 January 15; 288(1-2):194-6.






Hashimoto’s Encephalopathy Articles Published in 2011

Articles on Hashimoto’s Encephalopathy Published in 2011

Hashimoto’s encephalopathy in children and adolescents.

I. Erol, S. Saygi, F. Alehan

Pediatr Neurol. 2011 Dec;45(6):420-2.


Recurrent partial seizures with ictal yawning as atypical presentation of Hashimoto’s encephalopathy (steroid-responsive encephalopathy associated with autoimmune thyroiditis)

S. Casciatoa, C. Di Bonaventuraa, L. Lapentaa, J. Fattoucha, G. Ferrazzanoa, M. Fanellaa, F. Di Fabiob, M. Pasquinib, M.A. Amendoleac, M. Manfredia, d, M. Prencipea, A.T. Giallonardoa

Epilepsy & Behavior – December 2011 – Volume 22, Issue 4, pp.799–803


Encephalopathy associated with autoimmune thyroid disease (Hashimoto’s thyroiditis) presenting as depression: a case report.

CY Liu, MC Tseng, PH Lin

Gen Hosp Psychiatry. 2011 Nov-Dec;33(6):641.e7-9


Infectious disease or Hashimoto’s encephalopathy flares: a case report.

W Huang, C Xia, M Chatham

Seizure, 2011 Nov;20(9):717-9.


Steroid-responsive encephalopathy in autoimmune thyroiditis: clinical spectrum and MRI observations in three cases

K Dinkar, Sanjib Sinha, AB Taly, PS Bindu, RD Bharath

Annals of Indian Academy of Neurology: 2011  – Volume : 14  –  Issue : 3, pp. 205-207

Full Text:;year=2011;volume=14;issue=3;spage=205;epage=207;aulast=Dinkar

Central nervous system vasculitis with positive antithyroid antibodies in an adolescent boy.

Sarah L Tsai, Evan C Lewis, Erick Sell, Sharon Whiting

Pediatr Neurol. 2011 Sep ;45 (3):189-92


Spontaneous Remission of Encephalopathy Associated with Autoimmune Thyroid Disease in a Patient with Graves’ Disease: A Rare Occurrence in a Rare Clinical Picture

Y Elfaki, D O’Shea, and G Tamagno

Int J Endocrinol Metab. September 2011;9(4):373-6.

Full Text:

Non-convulsive status epilepticus of frontal origin as the first manifestation of Hashimoto’s encephalopathy.

G Monti, M Pugnaghi, A Ariatti, L Mirandola, G Giovannini, S Scacchetti, P Nichelli, S Meletti

Epileptic Disord. 2011 Sep;13(3):253-8.

Abstract / Full Text Available Free:

Hashimoto’s Encephalopathy: Systematic Review of the Literature and an Additional Case

Narriane Chaves P. de Holanda, M.D.; Denise Dantas de Lima, M.D.; Taciana Borges Cavalcanti, M.D.; Cynthia Salgado Lucena, M.D.; Francisco Bandeira, M.D., Ph.D.

The Journal of Neuropsychiatry and Clinical Neurosciences 2011;23:384-390.

Full Text:

Steroid-responsive encephalopathy and autoimmune thyroiditis in a young boy.

SD Shah, H Murali

Pediatr Neurol. 2011 Aug;45(2):132-4.


Steroid-responsive Hashimoto encephalopathy mimicking Creutzfeldt-Jakob disease

Santoro D, Colombo I, Ghione I, Peverelli L, Bresolin N, Sciacco M, Prelle A.

Neurol Sci. – Aug 2011 – Vol. 32, Issue 4, pp. 719-22


A Methodology for Assessing Treatment Response in Hashimoto’s Encephalopathy: A Case Study Demonstrating Repeated Computerized Neuropsychological Testing

Brian L. Brooks, PhD, Karen M. Barlow, MB, ChB, MRCPCH

Journal of Child Neurology June 2011 vol. 26 no. 6 786-791



Recurrent Hashimoto’s encephalopathy, showing spontaneous remission: a case report.

L Li, Zheng FP, Wang G, Li H.

Intern Med. 2011;50(12):1309-12. Epub 2011 Jun 15.

Abstract / Full Text Available Free:

Why the confusion in Hashimoto’s encephalopathy?

Bodiabaduge AP Jayasekera, Michael Anthony McShane, Prem Roy,and Geetha Anand
BMJ Case Rep. 2011; 2011: bcr0320114020. Published online 2011 June 16.
Full text at:


Progressive impairment of cognition and motor function: Hashimoto encephalopathy

Peter Tzakas and Sze Wan Sit

CMAJ. 2011 May 17; 183(8): E495–E497

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Hashimoto’s encephalopathy: a long-lasting remission induced by intravenous immunoglobulins.

Drulović J, Andrejević S, Bonaci-Nikolić B, Mijailović V.

Vojnosanit Pregl. 2011 May; Volume 68 – Issue 5 – pp. 452-4


A case of Hashimoto encephalopathy: clinical manifestation, imaging, pathology, treatment, and prognosis.

W Zhao, J Li, J Wang, Y Guo, H Tuo, Z Kang, B Jiang, R Wang, D Wang

Can J Neurol Sci. 2011 May ; 38 (3):404-10


Tremor and Myoclonus Heralding Hashimoto’s Encephalopathy

K. Gücüyener , A. Serdaroğlu, A. Bideci, Y. Yazman, A.S. Soysal, P. Cinaz

Journal of Pediatric Endocrinology and Metabolism, April 2011, Vol. 13, Issue 8, 1137-1141 (originally published 2000; updated)

First page:

Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) or Hashimoto’s encephalopathy: a case and review.

SW Lee, S. Donlon, JP Caplan.

Psychosomatics. 2011 Mar-Apr; Volume 52 – Issue 2 – pp. 99-108.


Time for the endocrinologists to expand their awareness of and contribution to the diagnosis and management of encephalopathy associated with autoimmune thyroid disease.

G Tamagno, G Gaoatswe

Hormones (Athens). 2011 Jan-Mar;10(1):36-8.

Full Text:

Hashimoto’s encephalopathy

Joana Ramalho, and Mauricio Castillo

Radiology Case Reports (Online) 2011;6:445 (January 2011)

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Presenile dementia: a case of Hashimoto’s encephalopathy.

CS Chong, JL Leung, IH Wong, PW Ng, MY Miao

East Asian Arch Psychiatry. 2011 Mar;21(1):32-6.

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Hashimoto’s encephalopathy in the setting of subclinical hypothyroidism

Vasile M Bota, Dominic F Corrigan

International Journal of Case Reports and Images, 2011 – Volume 2 – Issue 4 – pp. 19-22

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More precise definition of encephalopathy associated with autoimmune thyroid disease

Itai Berger

Acta Paedriactica: Volume 100, Issue 1, pages 5–6, January 2011 (Reader’s Forum)

By subscription or purchase only:

Manic Symptoms Associated With Hashimoto’s Encephalopathy: Response to Corticosteroid Treatment

Shuai-Ting Lin, Cheng-Sheng Chen, Pinchen Yang, Cheng-Chung Chen

The Journal of Neuropsychiatry and Clinical Neurosciences 2011;23:E20-E21 (Letter).

Full text:


Hashimoto’s Encephalopathy Articles Published in 2012

Articles on Hashimoto’s Encephalopathy Published in 2012

Paediatric autoimmune encephalopathies: clinical features,  laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens

Yael Hacohen, Sukhvir Wright, Patrick Waters, Shakti Agrawal, Lucinda Carr, Helen Cross, Carlos De Sousa, Catherine DeVile, Penny Fallon, Rajat Gupta, Tammy Hedderly, Elaine Hughes, Tim Kerr, Karine Lascelles, Jean-Pierre Lin, Sunny Philip, Keith Pohl, Prab Prabahkar, Martin Smith, Ruth Williams, Antonia Clarke, Cheryl Hemingway, Evangeline Wassmer, Angela Vincent, Ming J Lim

J Neurol Neurosurg Psychiatry. 2012 Nov 22.

Full text:

Autoimmune encephalitis in children. 

J Child Neurol. 2012 Nov;27(11):1460-9. Epub 2012 Aug 29.

T Armangue, M Petit-Pedrol, J Dalmau


Hashimoto’s Encephalopathy as the cause of deteriorating consciousness during treatment of Leptomeningeal Carcinomatosis from breast cancer

J Clin Oncol. 2012 Oct 8. [Epub ahead of print]

YH Liang, PF Wu, CH Lin, YS Lu

Extract (first page):

Anti-thyroid antibodies in two patients with subacute dementia, ataxia, and myoclonus

Daniel Kondziella, Klaus Hansen, Teresa Gonzalez, Peter Gideon, Ingelise Christiansen & Finn Sellebjerg

Ugeskr Læger 2012;174(9):577-579 (original in Danish; English translation available online)


A selective memory deficit caused by autoimmune encephalopathy associated with hashimoto thyroiditis.

C Koros, A Economou, G Mastorakos, A Bonakis, N Kalfakis, SG Papageorgiou

Cogn Behav Neurol. 2012 Sep;25(3):144-8.


Hashimoto’s encephalopathy presenting with multiple cranial nerve palsies and hemiparesis: A case report.

Saha S, Gupta RD, Mukherjee A, Singha A, Das D, Roy MK.

International Journal of Case Reports and Images 2012;3(5):31–35

Full Text:


Opsoclonus as a manifestation of Hashimoto’s encephalopathy.

R Salazar, C Mehta, N Zaher, D Miller D.

J Clin Neurosci. 2012 Aug 10. [Epub ahead of print]


A patient with steroid responsive encephalopathy associated with autoimmune thyroiditis.

BK Tsang, N Crump, AJ Hughes

J Clin Neurosci 2012 Aug 9.


Hashimoto’s encephalopathy

B B Chaigne, E E Beaufils, Y Y Jouan, J J Magnant, F F Maillot, T T Constans, C C Hommet and K K Mondon

Rev Med Interne 2012 Jul;33(7):390-5


Steroid-responsive encephalopathy associated with hashimoto thyroiditis.

Pediatric Radiol.  July 2012  – Volume  42, Issue 7, pp. 891-3.

P. Zimmermann, E. Stranzinger


Hashimoto encephalopathy presenting as progressive myoclonus epilepsy syndrome

R Arya, V Anand, M Chansoria.

Eur J Paediatr Neurol. 2012 Jul 25. [Epub ahead of print]


Hashimoto’s encephalopathy cases: Chinese experience

Yi Tang, Yi Xing, Michael T Lin, Jin Zhang and Jianping Jia

BMC Neurology 24 July 2012, 12:60


Full Text  (“provisional pdf” as of 8/27/12):


Hashimoto’s encephalopathy: neuropsychological findings.

I. Mazzù, S Mosti, C Caltagirone, GA Carlesimo

Neurol Sci. 2012 Jun;33(3):653-6.



Rituximab therapy in a patient with recurrent Hashimoto’s encephalitis, anti-GAD antibodies and progressive encephalomyelitis with rigidity and myoclonus

22nd Meeting of the European Neurological Society, Presentation on June 10, 2012 – Movement Disorders

D. Kassar, S. Damodaram, P. Chand, S. Iyadurai


Hashimoto encephalopathy and peripheral neuropathy in an Italian adolescent

V Salpietro, V Granata, A Polizzi, K Mankad, S Briuglia, R Gallizzi, G Tortorella, M Ruggieri

The Child Journal of Pediatrics, Vol 1, No. 2, June 2012: 9

Full text:

Pearls & Oy-sters: Hashimoto encephalopathy

Mitra Afshari, MD, MPH, Zahra S. Afshari, MD and Stephan U. Schuele, MD, MPH

Neurology May 29, 2012 vol. 78 no. 22 e134-e137

Full Text:

Steroid-responsive encephalopathy associated with autoimmune thyroiditis presenting as confusion, dysphasia, and myoclonus

S. A. Ryan, C. Kennedy, and H. J. Harrington

Case Reports in Medicine (Hindawi Publishing Corp.): Volume 2012

Full Text:

Hashimoto’s Encephalopathy

Gouranga Santra, Dibyendu De, Sibaji Phaujdar, Aniruddha Rudra, Partha Sarathi Dutta

Journal of the Association of Physicians of India – May 2012 – Vol. 60 – pp. 48-50

Full text:


Steroid-responsive encephalopathy associated with Graves’ disease

R. Dobrescu, D. Morosanu, S. Jercalau, C. Tiu & C. Badiu

European Society of Endocrinology, Endocrine Abstracts 2012 (May 2012), 29 P1708


Hashimoto Encephalopathy: A Rare Intricate Syndrome

J. Payer, T. Petrovic, L. Lisy, P. Langer

International Journal of Endocrinol Metab. April 2012 – Volume 10, Issue 2 – pp.506-14.

Full Text:

Hashimoto’s encephalopathy presenting with micrographia as a typical feature of parkinsonism.

K K Inoue, J J Kitamura, M M Yoneda, E E Imamura and H H Tokinobu

Neurol Sci. 2012 Apr;33(2):395-7


Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment

N Maroz, B Nechama, and RD Chow

Journal of Community Hospital Internal Medicine Perspectives 2012, Vol 2, 11453 (April 2012)

Full Text:

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis

Christian G. Bien, Angela Vincent, Michael H. Barnett, Albert J. Becker, Ingmar Blümcke, Francesc Graus, Kurt A. Jellinger, David E. Reuss, Teresa Ribalta, Jürgen Schlegel, Ian Sutton, Hans Lassmann and Jan Bauer

Oxford Journal: Brain, April 25, 2012 doi:10.1093/brain/aws082

Full text (free text of preliminary version – fee to obtain final article text) :

A case of Hashimoto’s encephalopathy presenting with seizures and psychosis.

Korean Journal of Pediatrics. 2012 Mar;55(3):111-3.

Lee MJ, Lee HS, Hwang JS, Jung DE.

Full Text:

Paroxysmal kinesigenic dyskinesia as the initial symptom of Hashimoto encephalopathy.

Ming-Yuan MY Liu, She-Qing SQ Zhang, Yong Y Hao and Hui-Min HM Zheng

CNS Neurosci Ther. 2012 Mar;18(3):271-3

Full Text:

Steroid-responsive encephalopathy subsequently associated with Alzheimer’s disease pathology: a case series

Farrah J. Mateen, Keith A. Josephs, Joseph E. Parisi, Daniel A. Drubach, Richard J. Caselli, Kejal Kantarci, Clifford Jack & Bradley F. Boeve

Neurocase – 2012 -Volume 18, Issue 1, pp. 1-12


Hashimoto encephalopathy causing drug-resistant status epilepticus treated with plasmapheresis.

Pediatr Neurol. 2012 Feb;46(2):132-5.

O Bektas, A Yılmaz, T Kendirli, Z Sıklar, G Deda


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AE Alliance
"The Autoimmune Encephalitis Alliance promotes collaboration to improve care, find a cure and create community so that no one faces autoimmune encephalitis alone.

The Encephalitis Society
"The Encephalitis Society is an International organization providing information and support for all causes of Encephalitis."

Encephalitis Global
"Encephalitis Global is a U.S.A. 501(c)(3) non-profit organization formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world."

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